• br METHODS br RESULTS br Discussion Numerous studies have

  2021-12-22

  

  METHODS RESULTS Discussion Numerous studies have proposed various hypotheses and models to explain how neuroinflammation could contribute to the chronic fatigue, postexertional fatigue, and cognitive deficits observed in patients with ME/CFS.12, 13, 14, 15 Although neuroimaging studies have

• Acknowledgment br Main Text From birth

  2021-12-22

  

  Acknowledgment Main Text From birth to adulthood, humans progressively acquire and maintain a complex microbial ecosystem at various body sites and cavities. Early on, these microorganisms establish a complex relationship with the host, resulting in the modulation of several biological functions

• Initial evidence that cell contact mediated transmission of

  2021-12-22

  

  Initial evidence that cell-contact-mediated transmission of HIV-1 is relevant for the generation of latently infected molecular mass calculator was suggested in the context of transmission from dendritic cells to resting CD4+ T cells (Evans et al., 2013, Kumar et al., 2015). As dendritic cells prob

• There is sufficient evidence to indicate

  2021-12-22

  

  There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH epothilone and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region of GnRH was clo

• Obestatin increased GnRH mRNA expression in

  2021-12-22

  

  Obestatin increased GnRH mRNA expression in the POA, being the main place of GnRH synthesis (Goodman, 2015). Simultaneously, obestatin also caused a decrease in the GnRH mRNA expression in ME, without affecting the level of this peptide mRNA in AHA. A lack of differences observed in the mRNA level i

• Initial studies generally focused on the co

  2021-12-22

  

  Initial studies generally focused on the co-administration of glutamate with transport inhibitors and clearly revealed the ability of the blockers to exacerbate excitotoxic injury in both in vitro and in vivo models (McBean & Roberts, 1985, Robinson et al., 1993a). In addition to demonstrating the c

• br Methods and materials br Results To examine the fear

  2021-12-22

  

  Methods and materials Results To examine the fear conditioning effects of the pre-exposure, drug, and sex factors in the total latency time, a 2 × 3 × 2 three-way ANOVA indicated that prolyl hydroxylase significant differences occurred in the drug (F2109 = 14.44, p 0.05) and pre-exposure × s

• br Acknowledgements Research was funded by the Natural Scien

  2021-12-22

  

  Acknowledgements Research was funded by the Natural Sciences and Engineering Council of Canada (NSERC) (Grant #210290) SGF. The funding body played no role in the design or execution of the study. The authors declare no conflict of interest. Introduction HBO2 therapy is the use of 100% oxygen

• Both anxiety like behavior and sucrose preference

  2021-12-22

  

  Both anxiety-like behavior and sucrose preference/intake were reduced in GPR40/FFAR1 KO male mice, while social behavior was normal in KO mice. These findings indicate that brain GPR40/FFAR1 is involved in the modulation of anxiety- and depression-like behavior in rodents. Previous studies have demo

• Thyroid hormone triiodothyronine T and its precursor

  2021-12-21

  

  Thyroid hormone 3,5,3′-triiodothyronine (T3) and its precursor, thyroxine (T4), are iodinated compounds, which are known to regulate the expression of genes involved in various biological processes, such as development, growth and metabolic control. The iodothyronine deiodinase types I, II and III (

• GlxI is a member of the superfamily

  2021-12-21

  

  GlxI is a member of the βαβββ superfamily of proteins, consisting of fosfomycin resistance protein (FosA), methylmalonyl-CoA epimerase (MMCE), extradiol dioxygenase (DIOX), mitomycin C resistance protein (MRP) and bleomycin resistance protein (BRP) [29], [30], [31]. These proteins are believed to ha

• The following are the supplementary data related

  2021-12-21

  

  The following are the supplementary data related to this article. Author contribution Conflict of interest Introduction Thrombosis (arterial and venous) is a major cause of vascular obstructive diseases including myocardial infarction, cerebral infarction and pulmonary embolism. Glycoprote

• Different from stable transfection transient expression

  2021-12-21

  

  Different from stable transfection, transient expression was also found to yield γ-secretase with robust proteolytic activity []. Co-transfection of all four, but not any three, components of human γ-secretase yielded high expression levels. This observation strongly suggests the co-folding nature o

• Studies have shown that coexpression of

  2021-12-21

  

  Studies have shown that coexpression of the HAC1 gene in P. pastoris improved the 6XHis level of foreign proteins [24,25]. By coexpression with PDI and Ero1, the expression level of the coexpressed strains was increased by 60% [26]. In our study, the α-galactosidase gene was coexpressed with four e

• br Materials and methods This is a retrospective

  2021-12-21

  

  Materials and methods This is a retrospective case-controlled study. The cases were selected based on the presence or absence of preeclampsia. Women enrolled in the study delivered singleton pregnancies at our institution from June 2003 to July 2004. Preeclampsia is defined as elevated blood pres

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