• A requirement for active PKA signaling during LTD induction

  2024-08-05

  

  A requirement for active PKA signaling during LTD induction was proposed in studies characterizing AKAP150 D36mice (Lu et al., 2008), but linking impaired LTD in D36 mice to PKA signaling deficits was complicated by subsequent work showing substantial increases in the number of dendritic spines and

• br cDNA cloning gene structure and chromosomal

  2024-08-05

  

  cDNA cloning, gene structure and chromosomal localization The cDNA for the leukocyte-type 12S-lipoxygenase was first cloned from porcine leukocytes [9], and later from mouse [10], [11], rat [12], [13], bovine [14] and rabbit [15] sources. The cDNA for the platelet-type 12S-lipoxygenase cDNA has b

• It has been largely demonstrated that several clinico pathol

  2024-08-05

  

  It has been largely demonstrated that several clinico-pathological factors influence ovarian cancer patients' prognosis, including residual tumor at primary cytoreductive surgery, FIGO stage, tumor grading, cancer histology and performance status [3,4]. Nevertheless, the recent awareness achieved in

• CHK has been reported to be the

  2024-08-03

  

  CHK1 has been reported to be the kinase responsible for H3.3S31 phosphorylation in human ALT cancer pcr master mix . However, in our study, knockdown of CHK1 in HEK293F (Figs. S1c and S6) or HeLa S3 (data not shown) cells did not result in a significant decrease in H3.3S31ph, which is in agreement w

• exemplifies three of the compounds

  2024-08-03

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC Radicicol as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degradation products. As

• br The role of apelin in cancer Studies on cancers

  2024-08-03

  

  The role of apelin in cancer Studies on cancers are intensively conducted worldwide. It is thought that this large family of diseases is among the most studied. The researchers test newly-discovered substances hoping to find remedies and diagnostic indices for this illness. One of such substances

• Using this cheese mimicking matrix we screened the

  2024-08-03

  

  Using this cheese-mimicking matrix, we screened the antifungal activity of 44 LAB fermented milk-based products and 23 LAB isolates used as protective cultures against 4 fungal targets. The LAB were obtained from the culture collections of CIRM-BIA (Centre International de Ressources Microbienne-Bac

• br Natriuretic peptides and neprilysin Left ventricular

  2024-08-03

  

  Natriuretic peptides and neprilysin Left ventricular systolic function, most commonly due to myocardial damage as a consequence of coronary artery disease, hypertension or both, and leading to sustained, pathological activation of the renin angiotensin 8-Azido-ATP system (RAAS) and sympathetic n

• Previous studies have thus demonstrated that AR activation g

  2024-08-03

  

  Previous studies have thus demonstrated that AR activation generally correlates with the promotion of urothelial carcinogenesis and cancer growth. In this article, we review available data suggesting their modulation through the AR pathway as well as correlations of AR signals with sensitivity to co

• To elucidate this relationship we developed a spatial model

  2024-08-03

  

  To elucidate this relationship, we developed a spatial model of Ca-influx through N-methyl-D-aspartate receptor (NMDAR), CaMKII/PP1 activation, and AMPAR insertion in a realistic spine geometry. Using this model, we show that i) variables in membrane voltage mediated Ca-influx, particularly the numb

• NNC 55-0396 Kuda et al reported that

  2024-08-02

  

  Kuda et al. (1997) reported that the activity of aminopeptidase A (ApA) but not aminopeptidase B (ApB) nor aminopeptidase N (ApN) was decreased in plasma from patients with Alzheimer's disease (AD). More recently Puertas et al. (2013) reported that the activities of plasma ApA, ApB, ApN and IRAP wer

• Some members from the AAAP family namely the AUX

  2024-08-02

  

  Some members from the AAAP family, namely the AUX1 and the LAX proteins, transport auxin instead of amino acids [48]. While there is some structural relationship between IAA and Trp, the substrate recognition characteristics seem different for these proteins: the auxins do not have any amino group o

• It has been reported that NLRP product caspase is increased

  2024-08-02

  

  It has been reported that NLRP3 product, caspase-1, is increased in the brains of AD patients and experimental AD animals. NLRP3- and caspase-1-deficient animals are resistant to experimental development of AD, and have decreased IL-1β production and significantly increased Aβ clearance (Heneka et a

• Introduction Aldose reductase ALR is the first enzyme of

  2024-08-02

  

  Introduction Aldose reductase (ALR2) is the first enzyme of the polyol pathway that catalyzes the reduction of glucose to sorbitol utilizing NADPH as a cofactor. The intracellular accumulation of sorbitol, due to increased aldose reductase activity at high blood glucose levels, such as those occurr

• Various compounds have been designed to inhibit

  2024-08-02

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic sch772984 moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a pot

16103 records 104/1074 page Previous Next First page 上5页 101102103104105 下5页 Last page