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Despite their undisputed importance however FPR receptors ar
2022-01-03
Despite their undisputed importance, however, FPR receptors are not in the limelight of GPCR-related research (for review [12] and references therein). We, therefore, draw attention to this GPCR receptor family, in order to re-initiate FPR-related research, particularly in the light of biased agonis
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Our previous study had shown that silencing
2022-01-03
Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β L-365,260 [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may be involved in the anti-l
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A great number of proteins entering the nucleus
2022-01-03
A great number of proteins entering the nucleus possess a characteristic nuclear localization sequence (NLS) in their primary structure. One of such sequences is the KKKGK motif [30]. It is present in all known muscle (but not liver – except human liver) FBPase sequences (human, rabbit, rat and mous
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The multiple sequence analysis showed that the putative amin
2022-01-03
The multiple sequence analysis showed that the putative amino glycogen synthase kinase 3 sequence of HbFDP had 80–99% identity to the FDPs from H. brasiliensis, Lupinus and T. wilfordii, Malus×domestica, Centella asiatica, M. sativa, M.recutita, accession H. annuus, and A. thaliana. The present resu
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The present study was designed to clarify
2022-01-03
The present study was designed to clarify the distribution and the function of the endothelin receptors in the guinea-pig urinary bladder. We found that endothelin-1 produced a clear tonic contraction via both ap15 subtypes, the endothelin ETA and ETB receptor, and that sarafotoxin S6c also induced
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The first wave of cells infiltrating heart shortly after
2022-01-03
The first wave of flavin adenine dinucleotide infiltrating heart shortly after MI is composed mainly of neutrophils, with the highest number on the first day after ischemic episode [101]. These cells are recruited via C-X-C motif chemokine ligand-2 (CXCL-2)- and CXCL-5-mediated chemotaxis. Both che
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